Biodegradable persistent ROS-generating nanosonosensitizers for enhanced synergistic cancer therapy by inducing cascaded oxidative stress

Nanoscale Horiz., 2024, 9,2306-2319
DOI: 10.1039/D4NH00189C, Communication

Yue Chen, Tong Ding, Zhengzheng Qian, Zerui Ma, Liming Zhou, Zhiling Li, Runkai Lv, Yinghui Xu, Yingjie Xu, Linhui Hao, Chen Zhu, Xikuang Yao, Wenying Yu, Wenpei Fan
Biodegradable CaO₂@PCN nanosonosensitizers induce sustained ROS production and mitochondrial calcium homeostasis via synergistic sonodynamic/ion interference therapy, ultimately leading to cancer cell death.
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