Nanoscale Horiz., 2019, Advance Article
DOI: 10.1039/C8NH00417J, Minireview
DOI: 10.1039/C8NH00417J, Minireview
Li Kong, Frederick Campbell, Alexander Kros
PEGylation of nanoparticles prolongs circulation lifetimes and maximizes nanoparticle accumulation in target tumors. However, PEGylation comes at the cost of reduced cellular uptake of nanoparticles and concomitant drug delivery. This review discusses the various stimuli-responsive dePEGylation strategies that have been employed to overcome this “PEG dilemma”.
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PEGylation of nanoparticles prolongs circulation lifetimes and maximizes nanoparticle accumulation in target tumors. However, PEGylation comes at the cost of reduced cellular uptake of nanoparticles and concomitant drug delivery. This review discusses the various stimuli-responsive dePEGylation strategies that have been employed to overcome this “PEG dilemma”.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry