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Viral capsid structural assembly governs the reovirus binding interface to NgR1

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Nanoscale Horiz., 2024, 9,1925-1937
DOI: 10.1039/D4NH00315B, Communication
Open Access Open Access
Rita dos Santos Natividade, Andra C. Dumitru, Alessandro Nicoli, Michael Strebl, Danica M. Sutherland, Olivia L. Welsh, Mustafa Ghulam, Thilo Stehle, Terence S. Dermody, Antonella Di Pizio, Melanie Koehler, David Alsteens
We reveal how viral capsid protein organization and curvature critically influence the stability of reovirus–NgR1 interactions, with distinct differences observed between single proteins, 2D assemblies, and 3D viral particles.
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