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Double-layered protein nanoparticles conjugated with truncated flagellin induce improved mucosal and systemic immune responses in mice

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Nanoscale Horiz., 2024, 9,2016-2030
DOI: 10.1039/D4NH00287C, Communication
Open Access Open Access
Joo Kyung Kim, Wandi Zhu, Chunhong Dong, Lai Wei, Yao Ma, Timothy Denning, Sang-Moo Kang, Bao-Zhong Wang
Intranasal immunization with HA3-tFliC/NP SDAD protein nanoparticles enhances both systemic and mucosal immunity, promoting influenza cross-protection. Sequential priming immunization further enhances GC B cells, Tfh cells, and effector T cells.
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