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Enhancing DNA-based nanodevices activation through cationic peptide acceleration of strand displacement

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Nanoscale Horiz., 2024, 9,1582-1586
DOI: 10.1039/D4NH00252K, Communication
Xianxue Zhang, Ruikai Du, Shichao Xu, Xinyue Wang, Zhen-Gang Wang
Cationic peptides, specifically oligoarginine, self-assemble with DNA to accelerate toehold-mediated DNA strand displacement reactions, enhancing the activation of DNA nanodevices such as tweezers and logic circuits, particularly under conditions of low ionic strength.
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