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Ultrafast sensitivity-controlled and specific detection of extracellular vesicles using optical force with antibody-modified microparticles in a microflow system

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Nanoscale Horiz., 2023, Advance Article
DOI: 10.1039/D2NH00576J, Communication
Open Access Open Access
Kana Fujiwara, Yumiko Takagi, Mamoru Tamura, Mika Omura, Kenta Morimoto, Ikuhiko Nakase, Shiho Tokonami, Takuya Iida
We propose a detection method of 103–104 nanoscale extracellular vesicles secreted from cancer cells and distinguish their multiple membrane proteins using controlled optical force and microfluidic pressure only by 5 minutes laser irradiation.
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