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Discrimination between protein glycoforms using lectin-functionalised gold nanoparticles as signal enhancers

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Nanoscale Horiz., 2023, 8,377-382
DOI: 10.1039/D2NH00470D, Communication
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Marta M. P. S. Neves, Sarah-Jane Richards, Alexander N. Baker, Marc Walker, Panagiotis G. Georgiou, Matthew I. Gibson
Biolayer interferometry is used to distinguish between glycoforms of the same using lectin-functional nanoparticles as both readers, and signal enhancers. The use of this is exemplified with prostate specific antigen.
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