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Polyclonal aptamer libraries as binding entities on a graphene FET based biosensor for the discrimination of apo- and holo-retinol binding protein 4

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Nanoscale Horiz., 2022, Advance Article
DOI: 10.1039/D1NH00605C, Communication
Ann-Kathrin Kissmann, Jakob Andersson, Anil Bozdogan, Valerie Amann, Markus Krämer, Hu Xing, Heinz Fabian Raber, Dennis H. Kubiczek, Patrik Aspermair, Wolfgang Knoll, Frank Rosenau
We report a sensor based on polyclonal aptamer libraries which is capable of label-free discrimination between retinol binding protein 4 isoforms (an important biomarker for kidney disease and diabetes) at sub-nM concentrations.
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