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Probing the mechanism of the peroxiredoxin decamer interaction with its reductase sulfiredoxin from the single molecule to the solution scale

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Nanoscale Horiz., 2022, 7,515-525
DOI: 10.1039/D2NH00037G, Communication
Audrey Beaussart, Florent Canonico, Hortense Mazon, Jorge Hidalgo, Sarah Cianférani, Hélène Le Cordier, Alexandre Kriznik, Sophie Rahuel-Clermont
A multiscale strategy based on AFM, native mass spectrometry and bulk solution techniques correlates affinity, kinetics, and single molecule data to understand regulation of the multivalent interaction of a decameric protein with its partner.
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