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Molecular recognition-driven supramolecular nanoassembly of a hydrophobic uracil prodrug and hydrophilic cytarabine for precise combination treatment of solid and non-solid tumors

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Nanoscale Horiz., 2022, Advance Article
DOI: 10.1039/D1NH00590A, Communication
Chang Li, Qiu Wang, Dan Li, Yubo Liu, Baichun Hu, Yao Feng, Haotian Zhang, Zhonggui He, Cong Luo, Jin Sun
The reduction sensitive supramolecular nanoassembly was based on U-SS-DOX and Ara-C specific molecular recognition. The drug release in the supramolecular nanoassembly was triggered and controlled in tumor cells with low pH and excessive GSH.
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