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Gene-editing by CRISPR–Cas9 in combination with anthracycline therapy via tumor microenvironment-switchable, EGFR-targeted, and nucleus-directed nanoparticles for head and neck cancer suppression

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Nanoscale Horiz., 2021, Advance Article
DOI: 10.1039/D1NH00254F, Communication
Chen-Shen Wang, Chih-Hsien Chang, Tsai-Yu Tzeng, Anya Maan-Yuh Lin, Yu-Li Lo
The smart nanoparticles may provide a combinatorial spatiotemporal platform against tumors for chemotherapy and the CRISPR/Cas gene-editing system with the advantages of a tumor pH response, active EGFR targeting, and nuclear localization.
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